Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
v1br_human | 21 | N-term | N => GlnfsTer11 | frameshift | 8.375e-06 | 1 | 119396 | 0 | None | None | ||
v1br_human | 71 | 2.41x41 | TM2 | L => AlafsTer156 | frameshift | 1.693e-05 | 2 | 118128 | 0 | None | None | |
v1br_human | 101 | 23.51x51 | ECL1 | Q => Ter | stop gained | 8.271e-06 | 1 | 120902 | 0 | None | None | |
v1br_human | 111 | 3.29x29 | TM3 | K => Ter | stop gained | 8.27e-06 | 1 | 120924 | 0 | None | None | |
v1br_human | 179 | ECL2 | Q => Ter | stop gained | 8.508e-06 | 1 | 117536 | 0 | None | None | ||
v1br_human | 183 | ECL2 | V => AlafsTer42 | frameshift | 8.51e-06 | 1 | 117508 | 0 | None | None | ||
v1br_human | 234 | 5.73x73 | TM5 | T => HisfsTer22 | frameshift | 5.063e-05 | 6 | 118512 | 0 | None | None | |
v1br_human | 235 | 5.74x74 | TM5 | Q => GlyfsTer77 | frameshift | 8.438e-06 | 1 | 118512 | 0 | None | None | GP (contact) |
v1br_human | 259 | ICL3 | T => SerfsTer53 | frameshift | 8.291e-05 | 10 | 120618 | 0 | None | None | ||
v1br_human | 278 | 6.32x32 | TM6 | R => Ter | stop gained | 8.249e-06 | 1 | 121228 | 0 | None | None | GP (contact) |
v1br_human | 336 | 7.51x51 | TM7 | W => Ter | stop gained | 1.703e-05 | 2 | 117466 | 0 | None | None | |
v1br_human | 354 | 8.59x59 | H8 | A => LeufsTer50 | frameshift | 8.964e-06 | 1 | 111556 | 0 | None | None | |
v1br_human | 355 | 8.60x60 | H8 | C => SerfsTer38 | frameshift | 9.003e-06 | 1 | 111078 | 0 | None | None | |
v1br_human | 377 | C-term | T => ProfsTer4 | frameshift | 9.369e-06 | 1 | 106738 | 0 | None | None | ||
v1br_human | 405 | C-term | E => ArgfsTer16 | frameshift | 8.399e-06 | 1 | 119056 | 0 | None | None | ||
v1br_human | 420 | C-term | E => Ter | stop gained | 2.546e-05 | 3 | 117836 | 0 | None | None | ||
v1br_human | 5 | N-term | P => S | missense | 0.0001224 | 14 | 114408 | 0 | 0.15 | 0.064 | ||
v1br_human | 8 | N-term | D => N | missense | 1.723e-05 | 2 | 116102 | 0 | 0.6 | 0.0 | ||
v1br_human | 9 | N-term | A => V | missense | 2.572e-05 | 3 | 116658 | 0 | 0.18 | 0.002 | ||
v1br_human | 10 | N-term | N => S | missense | 0.0001024 | 12 | 117134 | 0 | 0.66 | 0.001 | ||
v1br_human | 11 | N-term | P => T | missense | 8.52e-06 | 1 | 117368 | 0 | 0.16 | 0.007 | ||
v1br_human | 11 | N-term | P => H | missense | 8.509e-06 | 1 | 117526 | 0 | 0.07 | 0.027 | ||
v1br_human | 14 | N-term | R => W | missense | 0.0003719 | 44 | 118306 | 0 | 0.03 | 0.001 | ||
v1br_human | 19 | N-term | A => T | missense | 3.35e-05 | 4 | 119396 | 0 | 0.25 | 0.004 | ||
v1br_human | 21 | N-term | N => S | missense | 5.848e-05 | 7 | 119690 | 0 | 0.02 | 0.344 | ||
v1br_human | 24 | N-term | T => I | missense | 8.339e-06 | 1 | 119918 | 0 | 0.2 | 0.02 | ||
v1br_human | 26 | N-term | W => G | missense | 8.332e-06 | 1 | 120018 | 0 | 0.34 | 0.159 | ||
v1br_human | 35 | 1.33x33 | TM1 | K => Q | missense | 8.316e-06 | 1 | 120248 | 0 | 0.05 | 0.747 | |
v1br_human | 36 | 1.34x34 | TM1 | V => L | missense | 1.665e-05 | 2 | 120150 | 0 | 0.4 | 0.014 | |
v1br_human | 37 | 1.35x35 | TM1 | E => Q | missense | 8.324e-06 | 1 | 120134 | 0 | 0.0 | 0.998 | |
v1br_human | 38 | 1.36x36 | TM1 | I => M | missense | 1.667e-05 | 2 | 119998 | 0 | 0.02 | 0.935 | |
v1br_human | 48 | 1.46x46 | TM1 | A => V | missense | 2.522e-05 | 3 | 118964 | 0 | 0.0 | 0.951 | |
v1br_human | 55 | 1.53x53 | TM1 | V => M | missense | 9.274e-05 | 11 | 118610 | 0 | 0.02 | 0.641 | |
v1br_human | 58 | 1.56x56 | TM1 | T => I | missense | 3.379e-05 | 4 | 118374 | 0 | 0.04 | 0.006 | |
v1br_human | 58 | 1.56x56 | TM1 | T => N | missense | 8.448e-06 | 1 | 118374 | 0 | 0.0 | 0.228 | |
v1br_human | 59 | 1.57x57 | TM1 | L => P | missense | 1.692e-05 | 2 | 118202 | 0 | 0.0 | 0.966 | |
v1br_human | 60 | 1.58x58 | TM1 | G => S | missense | 8.456e-06 | 1 | 118254 | 0 | 0.36 | 0.915 | |
v1br_human | 62 | 1.60x60 | TM1 | L => R | missense | 8.46e-06 | 1 | 118204 | 0 | 0.15 | 0.004 | |
v1br_human | 64 | 12.49x49 | ICL1 | R => L | missense | 8.47e-06 | 1 | 118060 | 0 | 0.02 | 0.046 | |
v1br_human | 64 | 12.49x49 | ICL1 | R => H | missense | 8.47e-06 | 1 | 118060 | 0 | 0.33 | 0.027 | |
v1br_human | 65 | 12.50x50 | ICL1 | K => E | missense | 1.693e-05 | 2 | 118112 | 0 | 0.0 | 0.865 | |
v1br_human | 65 | 12.50x50 | ICL1 | K => N | missense | 0.04435 | 5241 | 118176 | 172 | 0.01 | 0.941 | |
v1br_human | 66 | 12.51x51 | ICL1 | R => L | missense | 8.47e-06 | 1 | 118058 | 0 | 0.42 | 0.019 | |
v1br_human | 66 | 12.51x51 | ICL1 | R => H | missense | 8.47e-06 | 1 | 118058 | 0 | 0.27 | 0.027 | |
v1br_human | 68 | 2.38x38 | TM2 | R => C | missense | 5.079e-05 | 6 | 118128 | 0 | 0.01 | 0.303 | |
v1br_human | 68 | 2.38x38 | TM2 | R => G | missense | 8.465e-06 | 1 | 118128 | 0 | 0.0 | 0.965 | |
v1br_human | 68 | 2.38x38 | TM2 | R => H | missense | 8.466e-06 | 1 | 118116 | 0 | 0.0 | 0.985 | |
v1br_human | 70 | 2.40x40 | TM2 | H => Y | missense | 1.692e-05 | 2 | 118180 | 0 | 0.2 | 0.896 | |
v1br_human | 73 | 2.43x43 | TM2 | V => M | missense | 0.0003969 | 47 | 118418 | 0 | 0.63 | 0.261 | |
v1br_human | 73 | 2.43x43 | TM2 | V => A | missense | 1.688e-05 | 2 | 118454 | 0 | 0.01 | 0.582 | |
v1br_human | 79 | 2.49x49 | TM2 | T => R | missense | 8.411e-06 | 1 | 118888 | 0 | 0.0 | 0.995 | |
v1br_human | 80 | 2.50x50 | TM2 | D => N | missense | 8.4e-06 | 1 | 119046 | 0 | 0.0 | 1.0 | |
v1br_human | 81 | 2.51x51 | TM2 | L => P | missense | 8.389e-06 | 1 | 119208 | 0 | 0.0 | 1.0 | |
v1br_human | 84 | 2.54x54 | TM2 | A => V | missense | 0.0001921 | 23 | 119726 | 0 | 0.0 | 1.0 | |
v1br_human | 84 | 2.54x54 | TM2 | A => E | missense | 8.352e-06 | 1 | 119726 | 0 | 0.0 | 1.0 | |
v1br_human | 85 | 2.55x55 | TM2 | L => F | missense | 8.337e-06 | 1 | 119950 | 0 | 0.96 | 0.202 | |
v1br_human | 85 | 2.55x55 | TM2 | L => H | missense | 8.33e-06 | 1 | 120052 | 0 | 0.0 | 0.975 | |
v1br_human | 85 | 2.55x55 | TM2 | L => P | missense | 1.666e-05 | 2 | 120052 | 0 | 0.0 | 0.975 | |
v1br_human | 88 | 2.58x57 | TM2 | V => L | missense | 8.31e-06 | 1 | 120332 | 0 | 0.02 | 0.961 | |
v1br_human | 92 | 2.62x61 | TM2 | L => V | missense | 8.288e-06 | 1 | 120660 | 0 | 0.0 | 0.676 | |
v1br_human | 96 | 2.66x65 | TM2 | I => V | missense | 1.655e-05 | 2 | 120848 | 0 | 0.38 | 0.039 | |
v1br_human | 99 | 23.49x49 | ECL1 | R => C | missense | 1.655e-05 | 2 | 120872 | 0 | 0.0 | 1.0 | |
v1br_human | 103 | 3.21x21 | TM3 | P => R | missense | 0.0001654 | 20 | 120916 | 0 | 0.0 | 0.943 | |
v1br_human | 104 | 3.22x22 | TM3 | D => N | missense | 1.654e-05 | 2 | 120922 | 0 | 0.0 | 1.0 | |
v1br_human | 107 | 3.25x25 | TM3 | C => R | missense | 8.269e-06 | 1 | 120936 | 0 | 0.0 | 1.0 | |
v1br_human | 110 | 3.28x28 | TM3 | V => I | missense | 6.615e-05 | 8 | 120934 | 0 | 0.12 | 0.126 | |
v1br_human | 111 | 3.29x29 | TM3 | K => M | missense | 4.135e-05 | 5 | 120924 | 0 | 0.0 | 0.999 | |
v1br_human | 113 | 3.31x31 | TM3 | L => V | missense | 7.444e-05 | 9 | 120906 | 0 | 0.0 | 0.942 | |
v1br_human | 115 | 3.33x33 | TM3 | V => A | missense | 7.445e-05 | 9 | 120888 | 0 | 0.03 | 0.058 | |
v1br_human | 122 | 3.40x40 | TM3 | T => S | missense | 0.0009518 | 115 | 120818 | 1 | 0.01 | 0.999 | SodiumPocket MicroSwitch |
v1br_human | 124 | 3.42x42 | TM3 | M => V | missense | 8.279e-06 | 1 | 120786 | 0 | 0.05 | 0.996 | |
v1br_human | 128 | 3.46x46 | TM3 | M => I | missense | 8.283e-06 | 1 | 120724 | 0 | 0.01 | 0.998 | |
v1br_human | 129 | 3.47x47 | TM3 | T => M | missense | 1.657e-05 | 2 | 120680 | 0 | 0.0 | 1.0 | |
v1br_human | 132 | 3.50x50 | TM3 | R => C | missense | 4.147e-05 | 5 | 120572 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch GP (contact) |
v1br_human | 132 | 3.50x50 | TM3 | R => H | missense | 7.466e-05 | 9 | 120548 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch GP (contact) |
v1br_human | 136 | 3.54x54 | TM3 | V => L | missense | 8.302e-06 | 1 | 120450 | 0 | 0.0 | 0.754 | GP (contact) |
v1br_human | 138 | 3.56x56 | TM3 | H => Q | missense | 7.488e-05 | 9 | 120200 | 0 | 0.29 | 0.961 | GP (contact) |
v1br_human | 142 | 34.53x53 | ICL2 | S => I | missense | 8.411e-06 | 1 | 118894 | 0 | 0.0 | 0.649 | GP (contact) |
v1br_human | 144 | 34.55x55 | ICL2 | Q => K | missense | 8.396e-06 | 1 | 119104 | 0 | 0.0 | 0.452 | GP (contact) |
v1br_human | 146 | 4.38x38 | TM4 | P => T | missense | 8.379e-06 | 1 | 119340 | 0 | 0.01 | 0.936 | |
v1br_human | 148 | 4.40x40 | TM4 | Q => P | missense | 8.379e-06 | 1 | 119352 | 0 | 0.01 | 0.566 | |
v1br_human | 149 | 4.41x41 | TM4 | S => F | missense | 8.382e-06 | 1 | 119306 | 0 | 0.03 | 0.038 | |
v1br_human | 151 | 4.43x43 | TM4 | Y => H | missense | 0.0001845 | 22 | 119244 | 0 | 0.15 | 0.094 | |
v1br_human | 153 | 4.45x45 | TM4 | L => F | missense | 8.399e-06 | 1 | 119064 | 0 | 0.04 | 0.094 | |
v1br_human | 158 | 4.50x50 | TM4 | W => C | missense | 1.69e-05 | 2 | 118350 | 0 | 0.0 | 1.0 | |
v1br_human | 162 | 4.54x54 | TM4 | A => S | missense | 8.431e-06 | 1 | 118612 | 0 | 0.19 | 0.167 | |
v1br_human | 172 | 4.64x65 | TM4 | F => S | missense | 1.698e-05 | 2 | 117804 | 0 | 0.0 | 1.0 | |
v1br_human | 172 | 4.64x65 | TM4 | F => L | missense | 3.396e-05 | 4 | 117778 | 0 | 0.0 | 0.999 | |
v1br_human | 174 | ECL2 | L => R | missense | 8.5e-06 | 1 | 117644 | 0 | 0.0 | 0.963 | ||
v1br_human | 175 | ECL2 | R => W | missense | 4.25e-05 | 5 | 117656 | 0 | 0.01 | 0.943 | ||
v1br_human | 175 | ECL2 | R => Q | missense | 4.25e-05 | 5 | 117642 | 0 | 0.13 | 0.072 | ||
v1br_human | 176 | ECL2 | E => Q | missense | 8.502e-06 | 1 | 117624 | 0 | 0.01 | 1.0 | ||
v1br_human | 176 | ECL2 | E => V | missense | 8.505e-06 | 1 | 117578 | 0 | 0.0 | 1.0 | ||
v1br_human | 185 | ECL2 | D => Y | missense | 8.51e-06 | 1 | 117514 | 0 | 0.0 | 1.0 | ||
v1br_human | 186 | 45.50x50 | ECL2 | C => F | missense | 1.702e-05 | 2 | 117514 | 0 | 0.0 | 1.0 | |
v1br_human | 187 | 45.51x51 | ECL2 | W => R | missense | 0.00485 | 570 | 117514 | 4 | 0.01 | 0.896 | |
v1br_human | 188 | 45.52x52 | ECL2 | A => E | missense | 1.702e-05 | 2 | 117494 | 0 | 0.0 | 1.0 | |
v1br_human | 189 | ECL2 | D => G | missense | 8.51e-06 | 1 | 117502 | 0 | 0.07 | 0.697 | ||
v1br_human | 191 | ECL2 | G => R | missense | 0.05254 | 6176 | 117558 | 223 | 0.66 | 0.003 | ||
v1br_human | 191 | ECL2 | G => S | missense | 2.552e-05 | 3 | 117558 | 0 | 0.28 | 0.084 | ||
v1br_human | 197 | 5.36x37 | TM5 | R => W | missense | 5.107e-05 | 6 | 117488 | 0 | 0.0 | 0.956 | |
v1br_human | 201 | 5.40x41 | TM5 | T => N | missense | 8.508e-06 | 1 | 117540 | 0 | 0.0 | 1.0 | |
v1br_human | 202 | 5.41x42 | TM5 | W => R | missense | 5.104e-05 | 6 | 117556 | 0 | 0.0 | 1.0 | |
v1br_human | 205 | 5.44x45 | TM5 | L => P | missense | 8.499e-06 | 1 | 117654 | 0 | 0.03 | 0.95 | |
v1br_human | 214 | 5.53x53 | TM5 | M => V | missense | 8.482e-06 | 1 | 117902 | 0 | 0.61 | 0.001 | |
v1br_human | 214 | 5.53x53 | TM5 | M => I | missense | 8.482e-06 | 1 | 117890 | 0 | 1.0 | 0.002 | |
v1br_human | 215 | 5.54x54 | TM5 | L => F | missense | 8.482e-06 | 1 | 117896 | 0 | 0.0 | 1.0 | |
v1br_human | 215 | 5.54x54 | TM5 | L => H | missense | 8.481e-06 | 1 | 117910 | 0 | 0.0 | 1.0 | |
v1br_human | 216 | 5.55x55 | TM5 | T => M | missense | 2.545e-05 | 3 | 117886 | 0 | 0.13 | 0.835 | |
v1br_human | 223 | 5.62x62 | TM5 | C => F | missense | 5.069e-05 | 6 | 118362 | 0 | 0.0 | 0.81 | |
v1br_human | 224 | 5.63x63 | TM5 | H => R | missense | 8.446e-06 | 1 | 118402 | 0 | 0.28 | 0.015 | |
v1br_human | 227 | 5.66x66 | TM5 | C => R | missense | 2.531e-05 | 3 | 118532 | 0 | 0.02 | 0.882 | GP (contact) |
v1br_human | 227 | 5.66x66 | TM5 | C => Y | missense | 1.687e-05 | 2 | 118540 | 0 | 0.06 | 0.052 | GP (contact) |
v1br_human | 228 | 5.67x67 | TM5 | K => T | missense | 8.434e-06 | 1 | 118570 | 0 | 0.02 | 0.969 | GP (contact) |
v1br_human | 235 | 5.74x74 | TM5 | Q => R | missense | 8.446e-06 | 1 | 118402 | 0 | 0.57 | 0.015 | GP (contact) |
v1br_human | 236 | 5.75x75 | TM5 | A => P | missense | 8.446e-06 | 1 | 118398 | 0 | 0.08 | 0.832 | GP (contact) |
v1br_human | 237 | 5.76x76 | TM5 | W => S | missense | 8.448e-06 | 1 | 118378 | 0 | 0.75 | 0.005 | |
v1br_human | 237 | 5.76x76 | TM5 | W => C | missense | 8.449e-06 | 1 | 118364 | 0 | 0.09 | 0.004 | |
v1br_human | 238 | ICL3 | R => W | missense | 5.916e-05 | 7 | 118314 | 0 | 0.0 | 0.72 | ||
v1br_human | 238 | ICL3 | R => P | missense | 8.445e-06 | 1 | 118414 | 0 | 0.16 | 0.477 | ||
v1br_human | 238 | ICL3 | R => L | missense | 2.533e-05 | 3 | 118414 | 0 | 0.09 | 0.138 | ||
v1br_human | 240 | ICL3 | G => V | missense | 2.522e-05 | 3 | 118972 | 0 | 0.21 | 0.02 | ||
v1br_human | 240 | ICL3 | G => E | missense | 1.681e-05 | 2 | 118972 | 0 | 1.0 | 0.003 | ||
v1br_human | 245 | ICL3 | R => S | missense | 8.345e-06 | 1 | 119836 | 0 | 0.26 | 0.257 | ||
v1br_human | 247 | ICL3 | W => C | missense | 8.333e-06 | 1 | 119998 | 0 | 0.13 | 0.016 | ||
v1br_human | 250 | ICL3 | P => S | missense | 8.323e-06 | 1 | 120154 | 0 | 0.54 | 0.018 | ||
v1br_human | 260 | ICL3 | R => W | missense | 1.657e-05 | 2 | 120702 | 0 | 0.1 | 0.017 | ||
v1br_human | 260 | ICL3 | R => Q | missense | 8.279e-06 | 1 | 120794 | 0 | 0.44 | 0.012 | ||
v1br_human | 260 | ICL3 | R => P | missense | 8.279e-06 | 1 | 120794 | 0 | 0.19 | 0.02 | ||
v1br_human | 261 | ICL3 | G => E | missense | 8.275e-06 | 1 | 120848 | 0 | 0.04 | 0.719 | ||
v1br_human | 263 | ICL3 | P => Q | missense | 8.268e-06 | 1 | 120954 | 0 | 0.5 | 0.882 | ||
v1br_human | 264 | ICL3 | S => F | missense | 8.266e-06 | 1 | 120974 | 0 | 0.01 | 0.977 | ||
v1br_human | 265 | ICL3 | R => W | missense | 4.132e-05 | 5 | 121002 | 0 | 0.02 | 0.991 | ||
v1br_human | 265 | ICL3 | R => L | missense | 4.132e-05 | 5 | 121016 | 0 | 0.04 | 0.899 | ||
v1br_human | 265 | ICL3 | R => Q | missense | 8.263e-06 | 1 | 121016 | 0 | 0.06 | 0.319 | ||
v1br_human | 267 | ICL3 | S => G | missense | 0.0007514 | 91 | 121102 | 1 | 0.01 | 0.999 | PTM (Phosphorylation) | |
v1br_human | 268 | ICL3 | S => G | missense | 8.255e-06 | 1 | 121142 | 0 | 0.02 | 0.186 | ||
v1br_human | 268 | ICL3 | S => N | missense | 8.255e-06 | 1 | 121146 | 0 | 0.06 | 0.954 | ||
v1br_human | 269 | ICL3 | I => T | missense | 8.254e-06 | 1 | 121160 | 0 | 0.06 | 0.032 | ||
v1br_human | 269 | ICL3 | I => N | missense | 1.651e-05 | 2 | 121160 | 0 | 0.0 | 0.845 | ||
v1br_human | 269 | ICL3 | I => M | missense | 8.253e-06 | 1 | 121164 | 0 | 0.0 | 0.882 | ||
v1br_human | 274 | 6.28x28 | TM6 | R => W | missense | 8.25e-06 | 1 | 121214 | 0 | 0.0 | 1.0 | GP (contact) |
v1br_human | 274 | 6.28x28 | TM6 | R => Q | missense | 5.775e-05 | 7 | 121218 | 0 | 0.02 | 1.0 | GP (contact) |
v1br_human | 278 | 6.32x32 | TM6 | R => Q | missense | 4.124e-05 | 5 | 121230 | 0 | 0.02 | 0.43 | GP (contact) |
v1br_human | 278 | 6.32x32 | TM6 | R => P | missense | 1.65e-05 | 2 | 121230 | 0 | 0.0 | 0.983 | GP (contact) |
v1br_human | 282 | 6.36x36 | TM6 | M => L | missense | 1.65e-05 | 2 | 121244 | 0 | 0.0 | 0.996 | GP (contact) |
v1br_human | 282 | 6.36x36 | TM6 | M => K | missense | 8.248e-06 | 1 | 121238 | 0 | 0.01 | 0.999 | GP (contact) |
v1br_human | 283 | 6.37x37 | TM6 | T => N | missense | 3.3e-05 | 4 | 121212 | 0 | 0.0 | 0.921 | GP (contact) |
v1br_human | 288 | 6.42x42 | TM6 | L => V | missense | 8.263e-06 | 1 | 121028 | 0 | 0.31 | 0.465 | |
v1br_human | 292 | 6.46x46 | TM6 | A => T | missense | 8.317e-06 | 1 | 120234 | 0 | 0.05 | 0.261 | |
v1br_human | 295 | 6.49x49 | TM6 | A => P | missense | 8.349e-06 | 1 | 119780 | 0 | 0.0 | 0.996 | |
v1br_human | 298 | 6.52x52 | TM6 | F => Y | missense | 8.407e-06 | 1 | 118948 | 0 | 0.0 | 0.999 | |
v1br_human | 301 | 6.55x55 | TM6 | Q => E | missense | 0.001084 | 128 | 118046 | 0 | 0.0 | 0.676 | |
v1br_human | 303 | 6.57x57 | TM6 | W => R | missense | 8.525e-06 | 1 | 117296 | 0 | 0.02 | 1.0 | |
v1br_human | 303 | 6.57x57 | TM6 | W => C | missense | 8.532e-06 | 1 | 117206 | 0 | 0.0 | 1.0 | |
v1br_human | 307 | 6.61x61 | TM6 | D => G | missense | 3.444e-05 | 4 | 116150 | 0 | 0.0 | 1.0 | |
v1br_human | 310 | ECL3 | A => V | missense | 8.686e-06 | 1 | 115124 | 0 | 0.23 | 0.958 | ||
v1br_human | 312 | ECL3 | D => H | missense | 6.984e-05 | 8 | 114542 | 0 | 0.49 | 0.056 | ||
v1br_human | 312 | ECL3 | D => N | missense | 8.73e-06 | 1 | 114542 | 0 | 0.78 | 0.014 | ||
v1br_human | 313 | ECL3 | E => K | missense | 0.0005784 | 66 | 114106 | 0 | 0.08 | 0.975 | ||
v1br_human | 314 | ECL3 | D => E | missense | 9.863e-06 | 1 | 101388 | 0 | 0.44 | 0.147 | ||
v1br_human | 318 | 7.33x32 | TM7 | V => E | missense | 1.841e-05 | 2 | 108624 | 0 | 0.1 | 0.424 | |
v1br_human | 323 | 7.38x37 | TM7 | S => F | missense | 3.499e-05 | 4 | 114306 | 0 | 0.0 | 0.882 | |
v1br_human | 324 | 7.39x38 | TM7 | M => V | missense | 8.709e-06 | 1 | 114818 | 0 | 0.07 | 0.465 | |
v1br_human | 324 | 7.39x38 | TM7 | M => I | missense | 8.68e-06 | 1 | 115204 | 0 | 0.03 | 0.91 | |
v1br_human | 326 | 7.41x40 | TM7 | L => S | missense | 0.000439 | 51 | 116176 | 0 | 0.0 | 1.0 | |
v1br_human | 329 | 7.44x43 | TM7 | L => I | missense | 8.535e-06 | 1 | 117168 | 0 | 0.01 | 0.367 | SodiumPocket MicroSwitch |
v1br_human | 334 | 7.49x49 | TM7 | N => H | missense | 8.49e-06 | 1 | 117782 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch |
v1br_human | 335 | 7.50x50 | TM7 | P => S | missense | 1.698e-05 | 2 | 117786 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch |
v1br_human | 339 | 7.54x54 | TM7 | M => I | missense | 8.545e-06 | 1 | 117022 | 0 | 0.0 | 0.098 | |
v1br_human | 346 | 8.51x51 | H8 | L => S | missense | 8.713e-06 | 1 | 114774 | 0 | 0.0 | 0.398 | GP (contact) |
v1br_human | 347 | 8.52x52 | H8 | P => L | missense | 2.63e-05 | 3 | 114080 | 0 | 0.17 | 0.003 | |
v1br_human | 348 | 8.53x53 | H8 | R => W | missense | 2.637e-05 | 3 | 113760 | 0 | 0.02 | 0.001 | |
v1br_human | 348 | 8.53x53 | H8 | R => Q | missense | 1.759e-05 | 2 | 113720 | 0 | 0.01 | 0.048 | |
v1br_human | 349 | 8.54x54 | H8 | P => A | missense | 8.804e-06 | 1 | 113584 | 0 | 0.71 | 0.003 | |
v1br_human | 350 | 8.55x55 | H8 | L => P | missense | 8.883e-06 | 1 | 112574 | 0 | 0.02 | 0.736 | |
v1br_human | 351 | 8.56x56 | H8 | R => C | missense | 1.779e-05 | 2 | 112414 | 0 | 0.05 | 0.01 | |
v1br_human | 351 | 8.56x56 | H8 | R => H | missense | 1.779e-05 | 2 | 112416 | 0 | 0.42 | 0.004 | |
v1br_human | 359 | C-term | P => T | missense | 9.139e-06 | 1 | 109426 | 0 | 0.42 | 0.075 | ||
v1br_human | 362 | C-term | R => S | missense | 1.872e-05 | 2 | 106852 | 0 | 0.31 | 0.002 | ||
v1br_human | 363 | C-term | M => V | missense | 1.882e-05 | 2 | 106268 | 0 | 0.28 | 0.001 | ||
v1br_human | 363 | C-term | M => T | missense | 9.479e-06 | 1 | 105498 | 0 | 0.19 | 0.036 | ||
v1br_human | 364 | C-term | R => C | missense | 9.647e-06 | 1 | 103664 | 0 | 0.07 | 0.002 | ||
v1br_human | 364 | C-term | R => H | missense | 0.134 | 13891 | 103670 | 1005 | 0.27 | 0.001 | ||
v1br_human | 364 | C-term | R => L | missense | 9.646e-06 | 1 | 103670 | 0 | 0.07 | 0.002 | ||
v1br_human | 365 | C-term | R => W | missense | 3.928e-05 | 4 | 101836 | 0 | 0.0 | 0.942 | ||
v1br_human | 365 | C-term | R => G | missense | 9.82e-06 | 1 | 101836 | 0 | 0.03 | 0.652 | ||
v1br_human | 365 | C-term | R => Q | missense | 0.0001859 | 19 | 102190 | 0 | 0.25 | 0.71 | ||
v1br_human | 366 | C-term | R => W | missense | 9.973e-05 | 10 | 100272 | 0 | 0.0 | 0.427 | ||
v1br_human | 369 | C-term | D => N | missense | 4.058e-05 | 4 | 98562 | 0 | 0.42 | 0.0 | ||
v1br_human | 370 | C-term | G => S | missense | 1.011e-05 | 1 | 98916 | 0 | 0.94 | 0.007 | ||
v1br_human | 370 | C-term | G => R | missense | 1.011e-05 | 1 | 98916 | 0 | 0.1 | 0.438 | ||
v1br_human | 371 | C-term | S => C | missense | 1.015e-05 | 1 | 98498 | 0 | 0.0 | 0.873 | PTM (Phosphorylation) | |
v1br_human | 371 | C-term | S => R | missense | 1.005e-05 | 1 | 99504 | 0 | 0.02 | 0.018 | PTM (Phosphorylation) | |
v1br_human | 372 | C-term | L => F | missense | 1.001e-05 | 1 | 99936 | 0 | 0.15 | 0.018 | ||
v1br_human | 373 | C-term | S => W | missense | 2.003e-05 | 2 | 99834 | 0 | 0.0 | 0.832 | ||
v1br_human | 373 | C-term | S => L | missense | 5.008e-05 | 5 | 99834 | 0 | 0.04 | 0.004 | ||
v1br_human | 374 | C-term | S => N | missense | 9.627e-06 | 1 | 103872 | 0 | 0.06 | 0.012 | ||
v1br_human | 375 | C-term | R => C | missense | 0.0004085 | 43 | 105260 | 0 | 0.0 | 0.88 | ||
v1br_human | 375 | C-term | R => H | missense | 5.696e-05 | 6 | 105346 | 0 | 0.01 | 0.782 | ||
v1br_human | 375 | C-term | R => P | missense | 9.493e-06 | 1 | 105346 | 0 | 0.0 | 0.866 | ||
v1br_human | 376 | C-term | H => Q | missense | 1.874e-05 | 2 | 106738 | 0 | 0.42 | 0.024 | ||
v1br_human | 378 | C-term | T => S | missense | 9.313e-06 | 1 | 107376 | 0 | 0.27 | 0.197 | ||
v1br_human | 378 | C-term | T => M | missense | 0.0001209 | 13 | 107534 | 0 | 0.03 | 0.134 | ||
v1br_human | 379 | C-term | L => R | missense | 2.772e-05 | 3 | 108236 | 0 | 0.04 | 0.999 | ||
v1br_human | 382 | C-term | R => C | missense | 9.11e-06 | 1 | 109770 | 0 | 0.05 | 0.011 | ||
v1br_human | 382 | C-term | R => H | missense | 1.818e-05 | 2 | 110038 | 0 | 0.43 | 0.004 | ||
v1br_human | 384 | C-term | S => G | missense | 8.966e-06 | 1 | 111534 | 0 | 0.06 | 0.004 | ||
v1br_human | 386 | C-term | P => L | missense | 0.000106 | 12 | 113162 | 0 | 0.07 | 0.004 | ||
v1br_human | 387 | C-term | A => V | missense | 8.757e-06 | 1 | 114190 | 0 | 0.05 | 0.034 | ||
v1br_human | 396 | C-term | T => S | missense | 8.489e-06 | 1 | 117806 | 0 | nan | 0.0 | ||
v1br_human | 396 | C-term | T => N | missense | 8.484e-06 | 1 | 117866 | 0 | nan | 0.004 | ||
v1br_human | 400 | C-term | R => T | missense | 3.374e-05 | 4 | 118550 | 0 | 0.29 | 0.036 | ||
v1br_human | 405 | C-term | E => K | missense | 8.394e-06 | 1 | 119136 | 0 | 0.15 | 0.022 | ||
v1br_human | 405 | C-term | E => G | missense | 8.39e-06 | 1 | 119194 | 0 | 0.21 | 0.001 | ||
v1br_human | 411 | C-term | E => D | missense | 8.388e-06 | 1 | 119214 | 0 | nan | 0.169 | ||
v1br_human | 415 | C-term | G => E | missense | 8.408e-06 | 1 | 118936 | 0 | nan | 0.018 | ||
v1br_human | 416 | C-term | E => V | missense | 8.424e-06 | 1 | 118706 | 0 | nan | 0.606 | ||
v1br_human | 419 | C-term | A => T | missense | 4.236e-05 | 5 | 118022 | 0 | 1.0 | 0.0 | ||
v1br_human | 423 | C-term | I => N | missense | 0.000308 | 36 | 116866 | 0 | nan | 0.118 | ||
v1br_human | 423 | C-term | I => T | missense | 8.557e-06 | 1 | 116866 | 0 | nan | 0.001 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue